منابع مشابه
Photolabelling of membrane proteins with photoactive phospholipids.
Photoactive probes have been introduced recently to study the hydrophobic sector of integral membrane proteins. A simple procedure to synthesize a new series of highly radioactive aryl azido-phospholipids is presented. They effectively exchange with the boundary lipids and, on illumination, the cross-link to several membrane proteins with high efficiency. The procedure and analysis of labelling...
متن کاملTissue Factor Residues That Putatively Interact with Membrane Phospholipids
Blood clotting is initiated by the two-subunit enzyme consisting of the plasma protease, factor VIIa (the catalytic subunit), bound to the integral membrane protein, tissue factor (the regulatory subunit). Molecular dynamics simulations have predicted that certain residues in the tissue factor ectodomain interact with phosphatidylserine headgroups to ensure optimal positioning of the tissue fac...
متن کاملHuntingtin associates with acidic phospholipids at the plasma membrane.
We have identified a domain in the N terminus of huntingtin that binds to membranes. A three-dimensional homology model of the structure of the binding domain predicts helical HEAT repeats, which emanate a positive electrostatic potential, consistent with a charge-based mechanism for membrane association. An amphipathic helix capable of inserting into pure lipid bilayers may serve to anchor hun...
متن کاملHuntingtin interactions with membrane phospholipids: strategic targets for therapeutic intervention?
The Huntington's disease gene encodes the protein huntingtin (Htt), a soluble protein that largely distributes to the cytoplasm where about half the protein is found in association with membranes. Early studies on Huntington's disease patients suggested changes in membrane phospholipids. Furthermore, changes in phospholipid biosynthetic enzymes have been found in HD cell models using genetic me...
متن کاملOn Membrane Phospholipids and Protein-lipid Association
Membranes of blood cells have an asymmetric bilayer distribution of phospholipid classes. In both erythrocytes and platelet plasma membranes the choline containing phospholipids (sphingomyelin and phosphatidylcholine) are preferentially located in the outer half of the membrane, whereas a large fraction of phosphatidylethanolamine and nearly all phosphatidylserine are confined to the cytoplasmi...
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ژورنال
عنوان ژورنال: Progress in Biophysics and Molecular Biology
سال: 1968
ISSN: 0079-6107
DOI: 10.1016/0079-6107(68)90019-9